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The next frontier in the genome sciences will be developing technology that captures novel quantitative biological measurements ... more about genomics
The Center for Biomedical Informatics (directed by PGFI member Peter White) at The Children's Hospital of Philadelphia has developed Genome Wowser (cost: free). Genome Wowser provides an iPad-enabled view of the human genome that is intuitive, highly portable and allows a “Google Maps”-like navigation experience of the popular UCSC Genome Browser.
Eukaryotic Pathogen Database Resources
EuPathDB Bioinformatics Resource Center for Biodefense and Emerging/Re-emerging Infectious Diseases is a portal for accessing genomic-scale datasets associated with the eukaryotic pathogens (Cryptosporidium, Giardia, Leishmania, Neospora, Plasmodium, Toxoplasma, Trichomonas and Trypanosoma).
Transcriptional regulation by sequence-specific transcription factors (TFs) is mediated, in significant part, by the post-translational modifications (PTMs) of the TFs. PTMs serve as ‘molecular switchboards’ that map upstream signaling events to the downstream transcriptional events. PTM-Switchboard is designed to catalog known cases of TF-PTMs affecting gene transcriptions. The current version 1.0 is limited to the model organism S. cerevisiae (budding yeast).
Related paper: Everett, L., A. Vo, and S. Hannenhalli, PTM-Switchboard--a database of posttranslational modifications of transcription factors, the mediating enzymes and target genes. Nucleic Acids Res, 2009. 37: p. D66-71.
The Spring 2013 newsletter can be viewed here.
Educational Facility Professional Development Workshops can be applied for here.
Interested in helping with genomics outreach? Add your name to our pool of volunteers and willing speakers/experts.
Based at the University of Pennsylvania, Penn Genome Frontiers Institute (PGFI) is a university-wide institute dedicated to the advancement of the interdisciplinary field of genomics research. PGFI fosters collaborations and scientific exchange across biology, veterinary medicine, pharmacology, medicine, genetics, microbiology, engineering, physics, chemistry and psychology. Our mission...