Single Cell Analysis Symposium

March 12, 2014 @ the University of Pennsylvania

Hold the date for this all-day symposium. Speakers include Nancy Allbritton, Helen Blau, Chi Dang, Jim Eberwine, Junhyong Kim, Christopher Murray, Garry Nolan, Arjun Raj and Sherman Weissman.

More details and registration here for this free event.


The next frontier in the genome sciences will be developing technology that captures novel quantitative biological measurements ... more about genomics

PGFI-enabled papers

The papers below are a selection of work that has been partially supported by PGFI funding or for which PGFI is listed in the author affiliations.


Burdick, J. and J. Murray (2013). "Deconvolution of gene expression from cell populations across the C. elegans lineage." BMC Bioinformatics 14(1): 204.

Drivas, T. G., E. L. F. Holzbaur and J. Bennett (2013). "Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration." The Journal of Clinical Investigation 123(10): 4525-4539.

Goodman, A. J., E. R. Daugharthy and J. Kim (2013). "Pervasive Antisense Transcription Is Evolutionarily Conserved in Budding Yeast." Molecular Biology and Evolution 30(2): 409-421.

Gregg, B., B. C. Taylor, B. John, E. D. Tait-Wojno, N. M. Girgis, N. Miller, S. Wagage, D. S. Roos and C. A. Hunter (2013). "Replication and Distribution of Toxoplasma gondii in the Small Intestine after Oral Infection with Tissue Cysts." Infection and Immunity 81(5): 1635-1643.

Kim, Tae K., J.-Y. Sul, H. Helmfors, U. Langel, J. Kim and J. Eberwine (2013). "Dendritic Glutamate Receptor mRNAs Show Contingent Local Hotspot-Dependent Translational Dynamics." Cell Reports.

Minot, S., A. Bryson, C. Chehoud, G. D. Wu, J. D. Lewis and F. D. Bushman (2013). "Rapid evolution of the human gut virome." Proceedings of the National Academy of Sciences 110(30): 12450-12455.

Moy, R. H. and S. Cherry (2013). "Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila." Journal of Innate Immunity 5(5): 444-455.

Nair, G., T. Walton, J. I. Murray and A. Raj (2013). "Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification." Development 140(16): 3385-3394.

Richards, J. L., A. L. Zacharias, T. Walton, J. T. Burdick and J. I. Murray (2013). "A quantitative model of normal Caenorhabditis elegans embryogenesis and its disruption after stress." Developmental Biology 374(1): 12-23.

Sabin, L. R., Q. Zheng, P. Thekkat, J. Yang, G. J. Hannon, B. D. Gregory, M. Tudor and S. Cherry (2013). "Dicer-2 Processes Diverse Viral RNA Species." PLoS ONE 8(2): e55458.

Spaethling, J. M. and J. H. Eberwine (2013). "Single-cell transcriptomics for drug target discovery." Current Opinion in Pharmacology(0).

Vandivier, L., F. Li, Q. Zheng, M. Willmann, Y. Chen and B. Gregory (2013). "Arabidopsis mRNA secondary structure correlates with protein function and domains." Plant Signaling & Behavior 8(6): e24301.

Willmann, M. R., N. D. Berkowitz and B. D. Gregory (2013). "Improved genome-wide mapping of uncapped and cleaved transcripts in eukaryotes—GMUCT 2.0." Methods(0).

Xu, J., K. Hopkins, L. Sabin, A. Yasunaga, H. Subramanian, I. Lamborn, B. Gordesky-Gold and S. Cherry (2013). "ERK signaling couples nutrient status to antiviral defense in the insect gut." Proceedings of the National Academy of Sciences 110(37): 15025-15030.

PGFI Announcements

The PGFI Fall 2013 Newsletter can be viewed here.

Educational Facility Professional Development Workshops can be applied for here.



Based at the University of Pennsylvania, Penn Genome Frontiers Institute (PGFI) is a university-wide institute dedicated to the advancement of the interdisciplinary field of genomics research. PGFI fosters collaborations and scientific exchange across biology, veterinary medicine, pharmacology, medicine, genetics, microbiology, engineering, physics, chemistry and psychology. Our mission...