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The next frontier in the genome sciences will be developing technology that captures novel quantitative biological measurements ... more about genomics
PGFI members pursue genomics research in one of Penn's 12 Schools, or in nearby institutions, including Children's Hospital of Philadelphia, The Wistar Institute, Thomas Jefferson College of Graduate Students and Monell Chemical Senses Center. Visit our members' pages to learn about the diversity of research performed by PGFI-affiliated investigators.
A selection of PGFI-enabled papers can be found here.
PGFI's Pilot Grant Program encourages innovation and technology development in the genome sciences by funding creative, often risky, projects. Through strategic investments in novel research, PGFI strives to empower the local research community to advance genomics globally.
Requests for applications are typically announced in the fall and spring (RFAs). Penn faculty members from any school are encouraged to apply.
Descriptions of PGFI-funded proposals can be viewed by clicking on the project title.
Dr. Marija Drndic
Real-time sizing/mass measurement and multi-channel detection of protein molecules extracted from electroporated live cells
Dr. Roger Greenberg
Dynamic imaging of ubiquitination at DNA double-strand breaks
Drs. Brian D. Gregory and Li-San Wang
Genome-wide analysis of the double-stranded RNA component of eukaryotic transcriptomes
Drs. Anna Kashina and Sergei Vinogradov
In vivo imaging of vesicle trafficking and its regulation by protein arginylation
Drs. Barry Cooperman, Yale Goldman and Todd Lamitina
Real-time proteomics (RTP) by single molecule fluorescence microscopy
Dr. Michael Lampson
Measuring phosphorylation dynamics in living cells: from local signaling networks to tumorigenesis
Drs. David Roos and Sara Cherry
Genome-wide siRNA screening in human macrophages to dissect mechanisms of cell-intrinsic immunity against the protozoan parasite Toxoplasma gondii
Dr. Susan Ross
Identification of intracellular molecules required for MMTV entry
Drs. David Artis, Frederic Bushman and Gary Wu
Immune Regulation of Mammalian Microbial Communities
Dr. Haig Kazazian
A Genomic Approach for Identifying New L1 Retrotransposition Events
The Spring 2013 newsletter can be viewed here.
Educational Facility Professional Development Workshops can be applied for here.
Interested in helping with genomics outreach? Add your name to our pool of volunteers and willing speakers/experts.
Based at the University of Pennsylvania, Penn Genome Frontiers Institute (PGFI) is a university-wide institute dedicated to the advancement of the interdisciplinary field of genomics research. PGFI fosters collaborations and scientific exchange across biology, veterinary medicine, pharmacology, medicine, genetics, microbiology, engineering, physics, chemistry and psychology. Our mission...