For information on how to be come a member click here.
To see list of Core members click here.
Monell Chemical Senses Center
http://www.monell.org/
Research interest: Dr. Bachmanov's primary research interests are the genetics of taste, ingestive behavior and alcohol intake. My research is based on genetic variation among mouse strains and leads to positional cloning of genes involved in taste-related behavior.
Pathology and Laboratory Medicine/Microarray Core http://www.med.upenn.edu/microarr/
Research interest: Dr. Baldwin is interested in utilizing genomics technologies for translational research.
Ophthalmology
http://www.med.upenn.edu/camb/faculty/gt/bennett.html
Research interest: Dr. Bennett's research focuses on developing somatic gene delivery for treatment of ocular diseases causing blindness. In preclinical studies, she has demonstrated reversal of blindness in dog and mouse models of a congenital blinding disease called Leber Congenital Amaurosis.
Pharmacology, SOM and Proteomics Core
http://www.med.upenn.edu/pharm/faculty/blair/blair.html
Research interest: Dr. Blair is interested in Oxidative stress in cancer and cardiovascular disease. On going studies involve an investigation of the role of endogenous DNA- and glutathione-adducts as biomarkers of cancer and cardiovascular disease in vitro, in animal models, and in human populations.
Biology
http://bonini.bio.upenn.edu/
Research Interests: Dr. Bonini uses the model organism Drosophila as a model to study human neurodegenerative disease. In particular, she has focused on Polyglutamine diseases, Parkinson's disease and RNA toxicity. The laboratory uses many techniques, including molecular biology, genetics and cell biology to define disease mechanisms and modifiers, then extend these findings back to the human disease situation.
Genetics
http://www.med.upenn.edu/ins/faculty/bucan.htm
Research interest: Dr. Bucan's laboratory is using classical genetic, genomic and bioinformatic approaches to determine genetic determinants of psychiatric disorders. These studies start with the genetic dissection of a complex psychiatric syndrome into components or endophenotypes, followed by forward genetic screens for corresponding behavioral anomalies in the mouse. Bioinformatic and computational approaches facilitate molecular characterization of behavioral mutants and selection of candidate genes for these mutants, as well as studies of their relevance to human disease.
Bioengineering
http://www.seas.upenn.edu/be/dir/details/JBurdickdetails.htm
Research interest: Dr. Burdick's research involves the development of biodegradable polymers for a number of tissue regeneration and drug delivery applications. All of the Burdick laboratory projects are focused on translational applications and they hope to motivate all towards clinical problems.
Microbiology
http://www.med.upenn.edu/camb/faculty/mv/bushman.html
Research interest: Dr. Bushman's laboratory uses genomic methods to study host-pathogen interactions.
Skirkanich Professor of Innovation in Bioengineering
http://www.med.upenn.edu/camb/faculty/cbp/chen.html
Research Interests: Regulation of angiogenesis, cancer growth, and stem cell differentiation by adhesive and mechanical cues, Mechanochemical signal transduction, Cadherin and integrin signaling, Rho GTPases and cytoskeletal processes, Cell and tissue engineering.
Pathology and Laboratory Medicine
http://www.med.upenn.edu/camb/faculty/gt/chen.html
Research interest: The major goals of Dr. Chen's research program are to understand the molecular mechanisms of autoimmune diseases (such as multiple sclerosis and type 1 diabetes) and to find a cure for these diseases. Dr. Chen's laboratory has recently performed functional genomic studies of autoimmune inflammation in the central nervous system (CNS) in order to explore the spectrum and global patterns of gene expression during autoimmune inflammation. Using models of inflammation, Dr. Chen and colleagues are exploring the physiological and pathological roles of the following genes: the Rel/nuclear factor (NF)-kB family, Bim and TRAIL.
Microbiology
http://www.med.upenn.edu/micro/faculty/cherry.html
Research interest: Dr. Cherry's laboratory uses high-throughput screening methodologies to identify small molecule inhibitors of viral replication. The identification of such compounds represents the first step in the development of new therapeutics. The viruses they study are important arthropod-borne human pathogens for which there are currently no efficacious drugs including West Nile virus, Dengue virus and Rift Valley Fever virus. Therefore, any inroads that they make will provide a stepping stone to new anti-virals.
Genetics/Pediatrics
http://genomics.med.upenn.edu/vcheung
Research interest: Dr. Cheung's research focuses on identifying the genetic determinants of human traits and developing tools that facilitate such studies.
Pathology and Laboratory Medicine, Penn
The Children's Hospital of Philadelphia
http://www.med.upenn.edu/camb/faculty/cgc/curran.html
Research interest: As part of the brain gene expression atlas project (GENSAT), the Curran laboratory is also analyzing gene expression in the brain using high-throughput in situ hybridization. They are taking genomic approaches to identify molecular changes and potential drug targets for several brain tumors including medulloblastoma, atypical teratoid/rhabdoid tumors and choroid plexus carcinomas. They developed a model system with a 100 percent incidence of spontaneous medulloblastoma for use in translational studies. Recently, they found that a small molecule inhibitor of the sonic hedgehog (Shh) pathway eliminated even large tumor masses in vivo. The Curran lab is continuing to analyze the mechanism of action of several anticancer drugs in tumor cells and cancer models.
Biology
http://www.bio.upenn.edu/faculty/daldal/
Research Interest: We are interested in the structure-function, regulation and biogenesis of cytochromes and cytochrome complexes in bacteria using combinations of molecular genetic, genomic, proteomic, biochemical and biophysical approaches.
CIS
http://www.cis.upenn.edu/~susan/
Research interest: Dr. Davidson's research interests include database systems, data modeling, and bioinformatics. Within bioinformatics she is best known for her work in data integration systems and scientific workflows.
Institute for Medicine and Engineering http://www.med.upenn.edu/camb/faculty/cbp/davies.html
Research interest: Dr. Davies is interested in quantitative aspects of vascular pathophysiology.
CDB
http://www.med.upenn.edu/sdinardo/Home.html
Research interest: Our lab has two areas of focus. First, through genomic-scale analyses, we have identified several genes whose expression is enriched in stem cells or their niche cells, and are studying their function as it relates to fundamental questions of stem and niche cell biology. Our second area of study concerns how developmental signals govern the complex cell biological outputs that guide morphogenesis.
Physics and Astronomy
http://www.physics.upenn.edu/~drndic/
Research interest: Dr. Drndic's lab is applying the unique capabilities of their recently developed sub-nanometer precision transmission electron beam ablation lithography (TEBAL) to demonstrate that the precise integration of solid-state nanopores with nanoelectrodes, nanochannels and microfluidics will address key obstacles that must be overcome to achieve nanopore-based low-cost high-speed single molecule analysis of proteins and DNA.
Pharmacology
http://www.med.upenn.edu/pharm/faculty/eberwine/eberwine.html
Research interest: The Eberwine lab performs fundamental work in elucidating how cells of the central nervous system communicate with one another. In particular, the lab has concentrated their efforts on developing novel methodologies that permit them to detect and quantify in vivo the influence of local subcellular environment on mRNA translation and gene transcription.
Cell and Developmental Biology
http://www.uphs.upenn.edu/cardio/faculty/epstein.html
Research interest: Dr. Epstein's laboratory studies the genetics and developmental biology of congenital disease and epigenetic modulation of cardiac growth.
Biology
http://www.bio.upenn.edu/faculty/ewens/
Research interest: Dr. Ewens works in three area of statistical genetics, namely evolutionary theory, the use of statistical methods to locate genes involved with diseases, and in bioinformatics. In evolutionary genetics his main interest is in developing statistical methods to detect "signatures of selection": this led to the development of the so-called Ewens sampling formula. In disease genetics he collaborated with Dr. Richard Spielman in developing the widely-used "transmission/disequilibrium" test. In bioinformatics his main interest is in the statistical theory associated with the appearance of various motifs in DNA sequences.
Biostatics and Epidemiology
Research interest: Developing statistical and comoutattional methods for analysis of genetic and genomic data, including methods of linkage and association analysis, in CNV analysis, and in epigenetics.
Pharmacology/ITMAT
http://www.med.upenn.edu/apps/faculty/index.php/g5165284/p9400
Research interest: Dr. FitzGerald is interested in the role of eicosanoids in inflammatory and cardiovascular disease and in the regulation and function of peripheral clocks.
Vice Provost for Research
http://www.vet.upenn.edu/FacultyandDepartments/Faculty/tabid/362/Default.aspx?faculty_id=20998
Cell and Developmental Biology
http://www.med.upenn.edu/apps/faculty/index.php/g20001040/p8213305
Associate Professor of Genetics
http://www.med.upenn.edu/apps/faculty/index.php/g5455356/p17894
Executive Vice Dean and Chief Scientific Officer
http://www.med.upenn.edu/camb/faculty/mv/gaulton.html
Psychiatry
http://www.med.upenn.edu/uep/faculty_goel.html
Research interest: Dr. Goel investigates how physiological, behavioral and environmental factors affect sleep, circadian rhythms and mood. She utilizes multidisciplinary and translational approaches bridging psychiatry, and behavioral neuroscience, clinical and biological psychology to show that environmental, non-drug stimuli substantially alter sleep and mood and modify circadian rhythms in clinical and non clinical populations. Thus, she conducts basic human translational research at the Phase I and II levels. Most recently, she has broadened her interests to include cognitive measures and genetics, and is identifying genes involved in differential vulnerability to partial sleep deprivation in humans.
Biochemistry
http://biochem.dental.upenn.edu/Mosaic/biochem_dept/golub.html
Research interest: Protein structure function analysis; prediction of protein structure from sequence: protein-protein interaction modeling
Biology
http://www.bio.upenn.edu/faculty/gregory/
Research interest: Dr. Gregory research is making use of genomic, bioinformatic, and systems biology approaches with molecular genetic and biochemical techniques. His lab is identifying and characterizing additional components required for the metabolism of various classes of small RNAs, as well as proteins involved in the regulation of specific small RNA populations and RNA silencing pathways. More specifically, we make use of high-throughput sequencing technologies to determine how the transcriptome as well as what small RNA populations are affected by these newly identified RNA silencing pathway components.
Pharmacology
http://www.med.upenn.edu/pharm/faculty/greenbaum/greenbaum.html
Research interest: Doron's laboratory focuses on developing and exploiting new technologies at the interface between biology and chemistry to study protease function. The lab uses a variety of techniques including the synthesis of small molecule inhibitors, quantitative proteomics, genomics, recombinant protein expression, and molecular genetics in order to better understand proteolytic systems. Although these tools are useful to study any biological system, my laboratory will initially concentrate much of its efforts to validate cysteine and serine proteases as potential therapeutic targets in the parasite P.falciparum, the causative agent of malaria.
Bioengineering
http://www.seas.upenn.edu/be/dir/details/daniel_hammer_details.html
Genetics
http://www.med.upenn.edu/apps/faculty/index.php/g306/p1999560
Research interest: We develop computational methods to investigate a variety of problems relevant to eukaryotic gene transcription and its evolution. The methods are applied to a number of biological domains in collaboration with experimental scientists.
Clinical Studies
http://www.vet.upenn.edu/FacultyandDepartments/Faculty/tabid/362/Default.aspx?faculty_id=3546221
Research interest: Dr. Henthorn's research activities focus on the molecular basis of simple and complex inherited disease, using naturally-occurring disease in dogs as a model system.
Pharmacology
http://bioinf.itmat.upenn.edu/hogeneschlab/
Research interest: Dr. Hogenesch's research program covers two areas of research, the biology of circadian clocks in the mammal, and the application of functional genomics tools to understanding genome function. By conducting research in two complementary areas of research, I hope to contribute to a better understanding of circadian clocks, as well as to the development of tools that can be broadly applied to other areas of research such as translational medicine. These tools can be employed to construct cell based models of important biological pathways, target identification using cDNA overexpression and RNAi interference, as well as small molecule screen development. Importantly, these approaches can be leveraged along with informatic, proteomic, and RNA dynamics strategies to better inform biology and physiology.
Monell Chemical Senses Center
http://www.monell.org/faculty_h.htm
Research interest: Dr. Huang's primary research interest is in molecular mechanisms underlying taste perception. With the completion of genome sequencing projects for humans, mice and other model organisms, nearly all genes in these genomes are identified, which presents an opportunity and challenge to elucidate genome-wide gene expression patterns for individual cells. I use single cell RT-PCR and other amplification methods, quantitative PCR and DNA arrays to establish global gene expression profiles for various morphological and physiological types of individual taste cells from taste buds. I utilize bioinformatics, molecular and biochemical methods to analyze gene expression patterns and to characterize gene products function in particular cells and to correlate cells "polygenotypes" with their physiological phenotypes. Results from these studies may contribute to uncovering taste cells' intra- and inter-cellular signaling networks and to a more complete understanding of taste perception.
Genetics
http://www.med.upenn.edu/kaestnerlab
Research interest: Dr. Kaestner's research is employing massively parallel sequencing to determine both epigenetic marks and transcription factor binding site across the entire mammalian genome. Applications are the determination of tissue specific gene expression, and the analysis of epigenetic changes that occur in diabetes.
Electrical and Systems Engineering
http://www.seas.upenn.edu/~kagan/
Biochemistry and Biophysics
http://www.uphs.upenn.edu/biocbiop/faculty/pages/kallen.html
Research Interest: Dr. Kallen's research deals with ion channel mediated transmembrane signal transduction. What do voltage-gated ion channels look like, how do they work in the presence and absence of modifiers and what regulates the expression of voltage-sensitive sodium channels in normal and pathologic states?
Animal Biology
http://www.med.upenn.edu/camb/faculty/cbp/kashina.html
Research interest: Genomes of higher mammals encode an estimated 40,000 proteins, however the complexity of the functions performed by these proteins in vivo is at least an order of magnitude higher. This complexity is achieved in a large part by posttranslational modifications that modulate structure and functions of proteins after synthesis. Dr. Kashina's research focuses on the biologic role of a poorly understood posttranslational modification - arginylation.
Genetics
http://www.med.upenn.edu/camb/faculty/ggr/kazazian.html
Research interest: Dr. Kazazian's research is on transposable elements in human and mammalian genomes. We are trying to develop methods to locate active LINE-1 elements in any human genome. This can be expanded to locating these elements in other mammalian genomes.
Biology
http://www.bio.upenn.edu/faculty/kim/
Research interest: Junhyong Kim is a computational biologist and evolutionary genomicist. His current work involves statistical methods for functional and comparative genomics, laboratory investigations of yeast cell-cycle evolution, data analysis for cancer genomics, and algorithm development for computational phylogenetics.
Pediatrics/Urology
http://www.chop.edu/consumer/pat_care_fam_serv/staff_profile_page.jsp?id=70344%20
Research interest: Molecular research aimed at the genes associated with the etiology of cryptorchidism and disorders of sex development and the long-term possibility of infertility. Molecular research (microarray of RNA) from the sperm of cryptorchid men to identify novel genes associated with poor seminal parameters.
Mechanical Engineering & Applied Mechanics
http://www.grasp.upenn.edu/~kumar/
Biology
http://www.med.upenn.edu/camb/faculty/cgc/lampson.html
Research interest: Dr. Lampson's research focuses on molecular mechanisms that maintain genome integrity during cell division. In particular, we use high resolution light microscopy, combined with molecular perturbations introduced by RNAi or with small molecule inhibitors, to examine key processes in cell division in real time in the context of living mammalian cells. These processes are critical to prevent aneuploidy, which is strongly associated with human cancer in somatic cells and with infertility and developmental defects in germ cells.
Biostatistics and Epidemiology
http://www.cceb.upenn.edu/faculty/index.php?id=18
Research interest: Dr. Landis' research is in development and evaluation of methods for the analysis of categorical data, with applications to cardiovascular, ophthalmology, respiratory, psychiatric, renal and urological research.
Endocrinology, Diabetes & Metabolism
http://www.med.upenn.edu/lazarlab/
Research interest: The Lazar laboratory is interested in mechanisms of diabetes, obesity, and metabolic diseases, and hopes to make discoveries that can be translated to the clinic.
Biostatistics and Epidemiology
http://www.cceb.upenn.edu/~hli
Research interest: Development of statistical, probabilistic and computational methods for analysis of high-dimensional genetic and genomic data, including methods linkage and association analysis in the context of the genome-wide association studies, methods for analysis genomic data with a graphical structures and methods for analysis of genetic pathways and networks.
Biostatistics and Epidemiology
http://www.cceb.upenn.edu/faculty/?id=159
Research interest: Developing statistical and computational tools for gene mapping of complex human diseases.
Biostatistics and Epidemiology
http://www.cceb.upenn.edu/faculty/?id=162
Research interest: Nandita Mitra, Ph.D. is Assistant Professor of Biostatistics in the Department of Biostatistics and Epidemiology at Penn. Her primary research interest is statistical genetics where she has worked extensively on SNP and haplotype problems in the context of family based and population based association studies. In addition, she has research interests in the theory of causal inference, propensity score methods and health economics. Dr. Mitra has collaborated primarily in the area of cancer research in the areas of breast, ovarian, skin, and prostate cancers. She recently collaborated on the first genome-wide association study of testicular cancer.
Medical Genetics
Research interest: Dr. Nathanson's primary focus of research is in cancer genetics. Her laboratory has research projects studying both genetic susceptibility to cancer (in high breast cancer and testicular cancer) and the somatic genetics of cancer (in melanoma and renal cancers.) Her research focuses on directly characterizing samples from patients an on translating cancer genetics into clinical care.
Associate Dean, Global Health Programs
http://www.med.upenn.edu/camb/faculty/mv/nathanson.html
CIS
http://www.cis.upenn.edu/~pereira/
Ophthalmology
http://www.med.upenn.edu/camb/faculty/ggr/pierce.html
Biology/Computer Science
http://www.bio.upenn.edu/faculty/plotkin/
Research interest: We use mathematics and computation to study questions in evolutionary biology and ecology. Research in the group is primarily concerned with the origin and maintenance of genetic variation within populations.
Biology
http://www.bio.upenn.edu/faculty/poethig/
Biology
http://www.bio.upenn.edu/faculty/pohlschroder/
Biostatistics and Epidemiology
http://www.cceb.upenn.edu/pages/rebbeck/rebbeck.htm
Monell Chemical Senses Center
http://www.monell.org/faculty_h.htm
Research interest: Dr. Reed's research program concerns the origins of individual differences in both rodent and human populations for behavior, body size and fat patterning. The assessment of heritability for complex behaviors and traits to determine their suitability for a genetics approach is the first step in this process, followed by the development and use of high-throughput techniques of genotyping and computation methods to assess the location and size of quantitative trait loci. The goal of this program is to understand the exact relationship between phenotype and genotype in human, mouse and rat populations for obesity and taste-related behaviors.
The Wistar Institute
http://www.wistar.upenn.edu/Riethman/research.htm
Research interest: Dr. Riethman is interested in: (1) the genomic structure, variation, and evolution of human subtelomere regions; (2) Telomere (TTAGGG) in tract length regulation and chromosome instability; and (3) biological impacts of short and/or dysfunctional telomeres on cancer and aging.
Pathology and Laboratory Medicine
http://www.med.upenn.edu/camb/faculty/gt/riley.html
Research interest: Our lab studies the signal transduction pathways that alter T cell activation and transform a T cell from a relatively inert cells to a rapidly dividing effector of the immune system.
Biology
http://www.bio.upenn.edu/faculty/roos/
Research interest: Molecular genetics, cell biology, and evolutionary genomics of protozoan parasites, including Plasmodium (malaria), and Toxoplasma.
Microbiology
http://www.med.upenn.edu/camb/faculty/mv/ross.html
Research interest: Dr. Ross' fields of expertise are in host-virus interactions, particularly retroviruses and New World arena viruses, and breast cancer. This includes developing models for testing therapeutics against viral infections via altering host responses. Additionally, because her lab discovered a novel signaling pathway potentially involved in breast cancer, they believe they may be able to target this pathway for treatment of this disease.
Pathology and Laboratory Medicine
http://www.med.upenn.edu/ins/faculty/schlaepfer.htm
Research interest: Identify interactive components that reduce neurotoxicity of abnormal protein aggregation in primary cultures and transgenic models of motor neuron degeneration.
Pathology, Anatomy and Cell Biology
http://www.jefferson.edu/jcgs/phd/neuroscience/behavioral_schwaber.cfm
Research interest: Dr. Schwaber uses systems biology approaches in mammalian brain to study adaptive neuronal processes. Specifically, his interests involve mechanisms by which hypertension arises in homeostatic cardio respiratory regulatory circuits, by which the symptoms of alcohol withdrawal are produced, and by which phase shifting of light causes the brain's master clock to reorganize circadian behavior.
Pediatrics
http://www.med.upenn.edu/camb/faculty/ggr/shaikh.html
Research interest: Dr. Shaikh's laboratory studies genetic diseases that arise due to structural abnormalities of the genome like microdeletions, micropduplications and translocations.
Orthopaedic Surgery
http://www.med.upenn.edu/camb/faculty/ggr/shore
Research interest: Human genetic diseases of bone formation. Shore et al Nature Genetics 2006 discovered that the human genetic disease fibrodysplasia ossificans progressiva (FOP) is caused by heterozygous mutation in the glycine-serine (GS) domain of the ACVR1/Alk2 gene, which encodes a BMP/TGF-beta family type I cell surface receptor. The GS domain of BMP type I receptors is a critical site for binding and activation of pathway-specific Smad signaling proteins and is a binding site of FKBP12, an inhibitory protein that prevents leaky activation of the type I receptor in the absence of ligand. An important goal of their research is the development of treatments for FOP and prevent the mis-regulated cartilage and bone cell differentiation that defines this condition. The identification of a recurrent mutation that causes FOP reveals a highly conserved and specific druggable target in the BMP/TGF-beta signaling pathway, and compels development and testing (in both in vitro and in vivo model systems) of therapeutic approaches.
Molecular & Cellular Oncogenesis
http://www.wistar.org/research_facilities/showe/research.htm
Research interest: Our research focuses on the development of Biomarkers for diagnosis, prognosis and treatment of cancer and auto-immune disease, using Microarray platforms and the Solexa Gene Analyzer, to assay gene and micro RNA expression and regulation. We also have developed new algorithms for gene expression analysis and microRNA and target detection. Major projects focus on the development of gene and microRNA expression signatures for the diagnosis of early stage lung cancer from peripheral blood and molecular measures of drug responses in clinical trials. The dual interest in cancer and responses of the immune system to cancer and other diseases is reflected by membership in both the Oncogenesis and Immunology Programs at Wistar.
Cell and Developmental Biology
http://www.med.upenn.edu/camb/faculty/cgc/simon.html
Research interest: Dr. Simon's laboratory is studying the genomics of renal clear cell carcinoma.
Genetics
http://www.med.upenn.edu/apps/faculty/index.php/g306/p19848
Research interest: We study natural variation in gene expression at the transcriptome level, and variation in response to agents that produce changes in gene expression.
Ophthalmology
http://www.med.upenn.edu/apps/faculty/index.php/g327/p5715
Research interest: Our lab is particularly interested in identifying gene variants that lead to human disease. Once identified, we analyze the variant for its effect on expression and protein structure.
Genetics
http://www.cbil.upenn.edu
Research interest: Biomedical data integration: databases, knowledge representation, and data modeling. Major projects include data integration related to eukaryotic pathogens and to diabetes. We are also involved in the development of biomedical data standards and their usage.
Computer and Information Science
http://www.cis.upenn.edu/~val/
Genetics and Biology
http://www.med.upenn.edu/tishkoff/
Monell Chemical Senses Center
http://www.monell.org/faculty_h.htm
Research interest: My research interests are broadly focused on taste and nutrition. One area involves topics related to mineral appetite, including calcium taste and appetite, the physiology of salt intake, appetite specificity, and how the postingestive consequences of minerals influence taste preferences. Another area involves the genetics of taste perception, including the preferences for alcohol, sweetness, saltiness and calcium. A third area involves characterizing the environmental contribution to individual differences, particularly the influences of early environment, husbandry procedures, and food choice on taste preferences and dietary obesity.
Pathology
http://www.med.upenn.edu/camb/faculty/cgc/tykocinski.html
Biology
http://www.bio.upenn.edu/faculty/wagner/
Research interest: Dr. Wagner's laboratory studies the role of a master transcriptional regulator and of chromatin remodeling in Arabidopsis using genomic and high throughput approaches including expression arrays, ChIP-chip, deletion mutagenesis followed by array CGH, and interactome mapping.
Monell Chemical Senses Center
http://www.monell.org/faculty_h.htm
Research interest: My primary research interest is to understand the molecular and cellular bases of taste and smell disorders.
Animal Biology
http://www.vet.upenn.edu/FacultyandDepartments/Faculty/tabid/362/Default.aspx?faculty_id=4485292
Research interest: Our lab is interested in studying chromosome segregation in homologous recombination using a combination of functional genomics, proteomics, and genetic approaches.
Pathology and Laboratory Medicine
http://www.med.upenn.edu/camb/faculty/gt/weiner.html
The Children's Hospital of Philadelphia
http://www.chop.edu/consumer/pat_care_fam_serv/staff_profile_page.jsp?sid=26696&id=74165
Pathology and Medical Genetics
http://www.med.upenn.edu/camb/faculty/gt/wolfe.html
Research interest: The Wolfe laboratory investigates direct gene transfer and neural stem cell engraftment in the CNS. Various vector systems and routes of delivery are being tested using animal disease models as a platform to evaluate therapeutic effectiveness. Most of the work has centered on the lysosomal storage diseases that, like most inherited metabolic disorders in the CNS, have global lesions. Advances in treatment of the mouse CNS are being extended to dog and cat models to study the significant scale-up barriers that must be overcome to effectively treat the human brain. Gene array and proteomics approaches are being used to study the molecular and cellular mechanisms responsible for brain dysfunction as well as to examine the changes induced by genetic correction.
Microbiology
http://www.med.upenn.edu/micro/faculty/zhu.html
Research interest: Dr. Zhu's laboratory applies functional genomic analysis to study roles of intra- and inter-species communication in human pathogen Vibrio cholerae pathogenesis and environmental survival.
Missed the Sept. 30 lecture-discussion on genomics & stem cells? Watch the video here.
Basic Wet Lab Techniques for Genomics Research Workshop (for faculty), Nov. 13-20 - more info.
The loss of PGFI-member and eminent geneticist Dr. Richard Spielman, 63, on April 25 was terribly sad for all of us who knew Dr. Spielman and his work. Information about the Richard Spielman Memorial Fund can be found here.
PGFI's Visiting Scholars program is soliciting nominations.