Research and Development Facilities
A primary mission of PGFI is to lead the development of new genomics technologies at Penn. In furtherance of this mission, PGFI houses three research and development facilities available for use by its members. In addition, it supports core facilities consisting of state-of-the-art centralized services and technologies that cannot be readily reproduced in individual laboratories in an efficient, cost-effective manner.
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Research Facilities
PGFI Provides
to Its Members
The facilities listed below are devoted to developing and implementing state-of-the-art genomics approaches that cannot be supported by existing cores or commercial services. The R&D facilities, equipment, expert personnel, and training are available to the members of the PGFI at a subsidized rate. Although the Facilities are "members-only", we allow members to sponsor others to use the facilities
The PGFI anticipates developing additional specialized cutting edge R&D facilities for use by PGFI members, as the PENN community need becomes apparent.
Core Facilities
Receiving Support from PGFI
The Core Facilities of the Penn Genome Frontiers Institute support University of Pennsylvania (PENN) investigators with state-of-the-art centralized services and technologies that cannot be readily reproduced in individual laboratories in an efficient, cost-effective manner. Each of the Core Facilities provides useful and appropriate services to PENN investigators and their collaborators at other institutions, with an emphasis on new and emerging technologies and specialty services.
Bioinformatics (Basic)
The Penn Bioinformatics Core (PBiC) provides computer resources, support and training to the University of Pennsylvania's biomedical research community. PBiC's goal is to ensure that scientists across the PENN community are able to effectively exploit existing and emerging computational technologies, especially related to genomics scale datasets.
Dr. John Tobias, Interim-Director
jtobias@pcbi.upenn.edu
1313-1316 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
215-573-4791
215-573-3111 (fax)
http://bioinformatics.upenn.edu/
DNA Sequencing
The Penn DNA Sequencing Facility provides sequencing services, template preparation/processing, DHPLC wave system services, microsatellite-based genotyping/fragment sizing and high-throughput sequencing at a discounted rate for investigators at the University of Pennyslvania's School of Medicine, the Abramson Cancer Center and the Penn Genome Frontiers Institute.
Dr. Tappan Ganguly, Director
gangulyt@mail.med.upenn.edu
B1 Richards Bldg. Basement
3700 Hamilton Walk/ 6085
215-573-7238
215-573-7407 (facility)
215-573-9327 (fax)
Contact email: dnaseq@mail.med.upenn.edu
http://www.med.upenn.edu/dnaseq/
Microarray
The Penn Microarray Facility provides instrumentation and expertise for RNA transcript profiling.
Dr. Don Baldwin, Director
dbaldwin@mail.med.upenn.edu
Office: 277 J. Morgan Bldg./6082
Instrumentation:210 J. Morgan Bldg., 1038 BRB II/III/6160
Sample preparation: 306 Stellar-Chance
215-898-3675
215-898-4227 (fax)
http://www.med.upenn.edu/microarr/
Molecular Diagnosis and Genotyping
The Molecular Diagnosis and Genotyping Facility provides molecular biology assays to investigators. Molecular assays are critical to many aspects of basic, clinical and population research, including molecular stratification of patients entering clinical protocols, molecular epidemiological and pharmacogenetic studies, as well as longitudinal follow-up of patients in clinical investigations. Single nucleotide polymorphism (SNP) genotyping has become central to the advancement of molecular genetics. At the Molecular Diagnosis and Genotyping Facility, we use the ABI Prism 7900HT allelic discrimination platform.
Dr. Don Baldwin, Director
dbaldwin@mail.med.upenn.edu
Dr. Kathakali
Addya
addya@mail.med.upenn.edu
7 E. Gates and Maloney Buildings
Hospital of the University of Pennsylvania
215-662-6589
215-614-1986 (fax)
http://www.med.upenn.edu/bmcrc/MDGF/index.shtml?MDGF
Proteomics
The Proteomics Facility, an integral component of the Penn Genome Frontiers Institute, provides and disseminates state-of-the-art scientific and technical knowledge in proteomics.
Dr. Ian Blair, Scientific Director
ian@spirit.gcrc.upenn.edu
853 BRB II/III/ Office
838 BRB II/III/ Facility
421 Curie Blvd.
Philadelphia, PA 19104-6160
215-573-9880
215-573-9889 (fax)
Dr. Chao-Xing Yuan, Technical Director
chaoxing@spirit.gcrc.upenn.edu
215-573-9883
215-573-9889
http://www.med.upenn.edu/ccp/cancer_pharm_bio.shtml